Uncoupling Transcription from Covalent Histone Modification
نویسندگان
چکیده
منابع مشابه
Uncoupling Transcription from Covalent Histone Modification
It is widely accepted that transcriptional regulation of eukaryotic genes is intimately coupled to covalent modifications of the underlying chromatin template, and in certain cases the functional consequences of these modifications have been characterized. Here we present evidence that gene activation in the silent heterochromatin of the yeast Saccharomyces cerevisiae can occur in the context o...
متن کاملUncoupling histone turnover from transcription-associated histone H3 modifications
Transcription in eukaryotes is associated with two major changes in chromatin organization. Firstly, nucleosomal histones are continuously replaced by new histones, an event that in yeast occurs predominantly at transcriptionally active promoters. Secondly, histones become modified post-translationally at specific lysine residues. Some modifications, including histone H3 trimethylation at lysin...
متن کاملHistoNer: Histone modification extraction from text
Systematic recognition of histone modifications in text is an important task to cope with the fast increase of biomedical literature. The high variability of phrases to express histone modifications renders keyword based search as insufficient for information retrieval. We present HistoNer, a rule based system for the recognition of histone modifications from text. Patterns are collected semi-a...
متن کاملToxoplasma gondii Inhibits Covalent Modification of Histone H3 at the IL-10 Promoter in Infected Macrophages
Infection of macrophages with the protozoan parasite Toxoplasma gondii results in inhibition of a large panel of LPS-responsive cytokines, including TNF-alpha, while leaving others such as IL-10 intact. Recent studies provide evidence that the parasite interferes with chromatin remodeling at the TNF-alpha promoter that is normally associated with LPS stimulation, but that is not required for TL...
متن کاملA novel lipid hydroperoxide-derived cyclic covalent modification to histone H4.
Previous studies have established that 4-hydroxy-2-nonenal is a lipid hydroperoxide-derived aldehydic bifunctional electrophile that reacts with DNA and proteins. However, it has now been recognized that 4-oxo-2-nonenal is also a major product of lipid hydroperoxide decomposition. Furthermore, 4-oxo-2-nonenal is more reactive than 4-hydroxy-2-nonenal toward the DNA-bases 2'-deoxyguanosine, 2'-d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2014
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1004202